![]() Only for treatment of the following documented life-threatening recurrent ventricular arrhythmias that do not respond to other antiarrhythmics or when alternative agents are not tolerated: Recurrent ventricular fibrillation, recurrent hemodynamically unstable ventricular tachycardia.Type III antiarrhythmic: Acts directly on cardiac cell membrane prolongs repolarization and refractory period increases ventricular fibrillation threshold acts on peripheral smooth muscle to decrease peripheral resistance.May be continued up to 96 hr or until rhythm is stable. For maintenance infusion, 540 mg at 0.5 mg/min over 18 hr. 1,000 mg IV over 24 hr-150 mg loading dose over 10 min, followed by 360 mg over 6 hr at rate of 1 mg/min.Adjust to the lowest possible dose to limit side effects. Loading dose: 800–1,600 mg/day PO in divided doses, for 1–3 wk reduce dose to 600–800 mg/day in divided doses for 1 mo if rhythm is stable, reduce dose to 400 mg/day in one to two divided doses for maintenance dose.The following is a guide to usual dosage. Therapy should begin in the hospital with continual monitoring and emergency equipment on standby. ![]() Careful patient assessment and evaluation with continual monitoring of cardiac response are necessary for titrating the dosage.Classification: Antiarrhythmic, Adrenergic blocker (not used as sympatholytic drug)
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